The antihypertensive effect of Olmesaratn medoxomil may be potentiated by drugs or other agents that lower blood pressure. An additive hyperkalaemic effect is possible with potassium supplements, potassium-sparing diuretics, or other drugs that can cause hyperkalemia; olmesartan medoxomil and potassium-sparing diuretics should not generally be given together. NSAIDs should be used with caution in patients taking olmesartan as the risk of renal impairment may be increased, particularly in those who are inadequately hydrated; use of NSAIDs may also attenuate the hypotensive effect of olmesartan medoxomil.
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