Olmepas Mechanism of Action

Pharmacology: Pharmacodynamics: Olmesartan Medoxomil is a potent, orally active, selective angiotensin II receptor (type AT1) antagonist. It is expected to block all actions of angiotensin II mediated by the AT1 receptor, regardless of the source or route of synthesis of angiotensin II. The selective antagonism of the angiotensin II (AT1) receptors results in increases in plasma renin levels and angiotensin I and II concentrations, and some decrease in plasma aldosterone concentrations.
Pharmacokinetics: Olmesartan medoxomil is an ester prodrug that is hydrolysed during absorption from the gastrointestinal tract to the active form olmesartan. The absolute bioavailability is about 26%. Peak plasma concentrations of olmesartan occur about 1 to 2 hours after oral doses. Olmesartan is at least 99% bound to plasma proteins. It is excreted in the urine and the bile as olmesartan; about 35 to 50% of the absorbed doses is excreted in the urine and the remainder in the bile. The terminal elimination half-life is between 10 and 15 hours.