Administered at a rate not exceeding 10 mg/min or at least 60 min.
Adult & adolescent >12 yr 2,000 mg IV in 4 divided doses every 6 hr or 1,000 mg IV every 12 hr.
Bacterial endocarditis 1,000 mg IV every 12 hr for 4 wk as monotherapy or in combination w/ other antibiotics (eg, gentamycin + rifampin, gentamicin, streptomycin).
Enterococcal endocarditis Duration: 6 wk in combination w/ aminoglycoside.
Peri-operative prophylaxis against bacterial endocarditis Adult 1,000 mg IV prior to surgery (before induction of anesth) followed by 1,000 mg IV every 12 hr post-op.
Childn 1 mth-12 yr 10 mg/kg every 6 hr or 20 mg/kg every 12 hr.
Infant & newborn 15 mg/kg, followed by 10 mg/kg every 12 hr during 1st wk of life & every 8 hr after & up to 1 mth.
Mild to moderate renal failure Starting dose: 15 mg/kg.
Severe renal failure Maintenance dose: 250-1,000 mg at several days interval.
Anuria Starting dose: 15 mg/kg until therapeutic serum conc is reached. Maintenance: 1.9 mg/kg daily.
Haemodialysis 1,000 mg IV saturating dose & 1,000 mg maintenance dose IV every 7-10 days. If polysulfone membranes are used, additional maintenance dose may be necessary.
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