Orsa Caution For Usage

Incompatibilities: Vancomycin solutions have a low pH value. This may lead to chemical or physical instability if mixed with other substances. Therefore, each parenteral solution should be checked visually for precipitations and discolouration prior to use.
This medicinal product must not be mixed with other medicinal products except those mentioned in Special precautions for disposal and other handling.
Combination therapy: In case of combination therapy of vancomycin with other antibiotics/chemotherapeutics, the preparations should be administered separately.
Mixtures of solutions of vancomycin and beta-lactam antibiotics have been shown to be physically incompatible. The likelihood of precipitation increases with higher concentrations of vancomycin. It is recommended to adequately flush the intravenous lines between administration of these antibiotics. It is also recommended to dilute solutions of vancomycin to 5 mg/mL or less.
Special precautions for disposal and other handling: The product must be reconstituted and the resulting concentrate must then be diluted prior to use.
Preparation of the reconstituted solution: Dissolve Vancomycin 500 mg Powder for solution for infusion in 10 ml of sterile Water for injection.
One ml of reconstituted solution contains 50 mg of vancomycin.
Appearance of reconstituted solution: After reconstitution the solution is clear and colorless to slightly yellowish brown without visible particles.
Appearance of diluted solution: After dilution the solution is clear and colorless without visible particles.
Disposal: Vials are for single use only. Unused medicinal products must be discarded.
Any unused medicinal product or waste material should be disposed of in accordance with local requirements.