Qvex Dosage/Direction for Use

Schizophrenia: The usual initial daily dose in schizophrenia is the equivalent of 50 mg of the base on day one. The dose is increased on days two and three in increments of 50 to 150 mg, as tolerated, to a target of 300 to 400 mg daily by day four. The daily dose on the first day is given in 2 divided doses, but may be given in 3 divided doses thereafter. The daily dosage may be further adjusted as necessary in steps of 50 to 100 mg at intervals of not less than 2 days to a maximum daily of dose 750 mg.
In the treatment of acute manic episodes associated with bipolar disorder: The initial dose is 50 mg twice daily on day one, 100 mg twice daily on day two, 150 mg twice daily on day three, and 200 mg twice daily on day four. The dose may then be adjusted according to response to a usual range of 400 to 800 mg daily, although in some patients, 200 mg daily may be adequate. Increments in dosage should be no greater than 200 mg daily.
Quetiapine used in the depressive phase of bipolar disorder: The initial dose is 50 mg once daily at bedtime increased to 100 mg on day two, 200 mg on day three, and 300 mg on day four. The dose may be further increased to 400 mg on day five and 600 mg on day eight, if necessary. For the maintenance treatment of bipolar disorder as an adjunct to lithium or valproate; patients should be continued on the dose that controlled their initial symptoms.
Quetiapine should be given in reduced doses for elderly patients: A recommended starting dose is 25 mg daily, which may be increased every day in increments of 25 to 50 mg according to response; the effective dose range is likely to be lower than in younger adults. Reduced doses are also recommended in patients with hepatic or renal impairment.
Administration in hepatic or renal impairment: Quetiapine should be given in reduced doses to patients with hepatic impairment; a recommended initial oral dose is 25 mg daily, increased in steps of 25 to 50 mg daily according to response.