Schizophrenia Initially 50 mg daily on day 1, increased in increments of 50-150 mg as tolerated on days 2 & 3 to a target of 300-400 mg daily by day 4. Daily dose on day 1 is given in 2 divided doses but may be given in 3 divided doses thereafter. Daily dose may be further adjusted as necessary in steps of 50-100 mg at intervals of not <2 days to max daily dose of 750 mg.
Acute manic episodes associated w/ bipolar disorder Initially 50 mg bid on day 1, 100 mg bid on day 2, 150 mg bid on day 3 & 200 mg bid on day 4. Dose may then be adjusted to 400-800 mg daily according to response. Increments should be no >200 mg daily.
Depressive phase of bipolar disorder Initially 50 mg once daily at bedtime, increased to 100 mg on day 2, 200 mg on day 3 & 300 mg on day 4. Dose may be further increased to 400 mg on day 5 & 600 mg on day 8 if necessary.
Maintenance treatment of bipolar disorder as adjunct to lithium or valproate Continue dose that controlled initial symptoms.
Elderly & hepatic impairment Initially 25 mg daily, may be increased in increments of 25-50 mg daily according to response.
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