Agranulocytosis (<500/mm3) has been reported occasionally at a total of cumulative dose exceeding 20 g. Exanthemia, allergic dermatitis, pruritus, urticarial, edema, erythema multiforme also occurred. Other side effects such as headaches, dizziness, increase in serum creatinine, mycosis of genital tract, oliguria, fever, and shivering have been observed. Anaphylactic shock may occur which requires immediate counter-measures. On the site of administration, pain, induration, and tenderness may be encountered. Inflammatory reactions in the vein wall may also occur after IV administration. These may be minimized by slow injection, given over 2 to 5 minutes.
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