Susceptible infections including resp tract, enteric fever, UTI, otitis media. Gonorrhea. Sequential treatment after initial IV chemotherapy after parenteral cephalosporin.
Adult & childn >12 yr 400 mg as a single dose or in 2 divided doses. Childn 8 mg/kg/day as single or in 2 divided doses. Renal impairment CrCl >60 mL/min Usual dose; 21-60 mL/min or on hemodialysis 75% standard dose at standard dosing interval; 20 mL/min or on continuous ambulatory peritoneal dialysis ½ standard dose at standard dosing interval. Course of treatment: 7-14 days.
Penicillin-sensitive patients. Discontinue use if allergic effect occur. May permit overgrowth of clostridia. Severe antibiotic-associated diarrhea including pseudomembranous colitis. Markedly impaired renal function. History of GI disease particularly colitis. False +ve reaction in urine w/ nitroprusside testing, Benedict's or Fehling's soln or w/ copper sulfate test cap, Coombs' test. Pregnancy & lactation. Childn <6 mth.
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