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Cefixime should be given with caution to patients who have shown hypersensitivity to penicillins, cephalosporins or other drugs. Cephalosporins should be given with caution to penicillin sensitive patients, as there is some evidence of partial cross-allergenicity between the penicillins and the cephalosporins. Patients have had severe reactions (including anaphylaxis) to both classes of drugs. If an allergic effect occurs with Cefixime, the drug should be discontinued and the patient treated with appropriate agents if necessary.
Treatment with broad spectrum antibiotics, including Cefixime alters the normal flora of the colon and may permit overgrowth of clostridia. Studies indicate that a toxin produced by Clostridium difficile is a primary cause of severe antibiotic-associated diarrhea including pseudomembranous colitis.
