Other ototoxic or nephrotoxic drugs, such as the aminoglycosides, polymyxins, and loop diuretics, markedly increase the risk of toxicity and should be given concomitantly with vancomycin only with great caution. Some of adverse effects of vancomycin may be enhanced by the concurrent use of general anaesthesia. Vancomycin may increase neuromuscular blockade produced by drugs such as suxamethonium or vecuronium.
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