Vancomax Mechanism of Action

Antibacterial.
Pharmacology: Pharmacokinetics: Vancomycin is only poorly absorbed from the gastrointestinal tract, although absorption may be somewhat greater when gastrointestinal tract is inflamed. Intramuscular administration is associated with pain and tissue necrosis; systemic doses are therefore given intravenously. Infusion of a 1-g dose intravenously over 60 minutes has reportedly been associated with plasma concentrations of up to about 60 μg per mL immediately after completion of the fusion, and about 25 μg per mL 2 hours later, falling to under 10 μg per mL after 11 hours. However, there may be considerable interindividual variation in the pharmacokinetics of vancomycin: a range of half-lives between 3 and 13 hours has been reported, with an average of about 6 hours, in patients with normal renal function. Half-life may be prolonged in patients with renal impairment, to 7 days or more anephric patients. About 55% is bound to plasma protein, although large variations have been reported.