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CEFUROXIME is administered by mouth as the acetoxyethyl ester, cefuroxime axetil in the form of tablets or suspension or by injection as the sodium salt. Cefuroxime sodium may be given by deep intramuscular injection by slow intravenous injection over 3 to 5 minutes or by intravenous infusion. Doses of Cefuroxime axetil and Cefuroxime sodium are expressed in terms of the equivalent amount of cefuroxime.
URINARY TRACT INFECTION: Usual oral doses are 125mg twice daily.
RESPIRATORY TRACT INFECTION: 250 to 500mg twice daily.
INFANTS AND CHILDREN: A suggested dose for children more than 3 months of age is 125mg twice daily or 10mg/kg body weight twice daily to a maximum of 250mg daily.
CHILDREN over 2 years of age with otitis media may be given 250mg twice daily or 15mg/kg twice daily to a maximum of 500mg daily.
RENAL IMPAIRMENT: The parenteral doses may need to be reduced. The usual adult dose of 750mg should only be given twice daily when the creatinine clearance is between 10 and 20mL per minute and once daily when it is below 10mL per minute.
MENINGITIS: Administered intravenously in doses of 3g every 8 hours.
GONORRHOEA: Single dose of 1.5g by intramuscular injection, divided between 2 injection sites, has been suggested. A single 1g oral dose of cefuroxime has been given for uncomplicated gonorrhea.
PROPHYLAXIS: The usual dose is 1.5g of cefuroxime intravenously prior to procedures. This may be supplemented by 750mg intravenously every 8 hours for up to 24 to 48 hours depending upon the procedure. For total joint replacement, 1.5g of cefuroxime powder may be mixed with the methyl methacrylate cement.
