Xefu Indications/Uses

CEFUROXIME is bactericidal and has a similar spectrum of antimicrobial action and pattern of resistance to that of cephamandole. It is more resistant to hydrolysis by beta-lactamases than cephamandole, and therefore may be more active against beta-lactamases-producing strains of, for example, Haemophilus influenzae and Neisseria gonorrhoeae. However, treatment failures have occurred in patients with H. influenzae meningitis given cefuroxime and might be associated with a relatively high minimum bactericidal concentration (MBC) when compared with the minimum inhibitory concentration (MIC) or with significant inoculum effect. Reduced affinity of penicillin-binding proteins for cefuroxime has also been reported responsible for resistance in a beta-lactamase-negative strain of H. influenzae.
CEFUROXIME is a second generation cephalosporin antibiotic used in the treatment of susceptible infections. These include bone and joint infections, bronchitis (and other lower respiratory tract infections), gonorrhea, meningitis (although treatment failures have been reported in H. influenzae meningitis), otitis media, peritonitis, pharyngitis, sinusitis, skin infections (including soft-tissue infections), surgical infection (prophylaxis) and urinary-tract infections.