Tab Adult & adolescent ≥13 yr Acute sinusitis, acute tonsillopharyngitis, acute bacterial exacerbations of chronic bronchitis, uncomplicated skin & skin structure infections 250 or 500 mg every 12 hr for 10 days.
Acute otitis media 500 mg every 12 hr for 10 days.
Uncomplicated gonorrhea 1,000 mg once as single dose.
Secondary bacterial infections of acute bronchitis 250 or 500 mg every 12 hr for 5-10 days.
Uncomplicated UTI 250 or 500 mg every 12 hr for 7-10 days.
Early Lyme disease 500 mg every 12 hr for 20 days.
Childn 7-12 yr Acute sinusitis, acute otitis media, acute tonsillopharyngitis, acute bacterial exacerbations of chronic bronchitis, uncomplicated skin & skin structure infections 250 mg every 12 hr for 10 days.
Secondary bacterial infections of acute bronchitis 250 mg every 12 hr for 5-10 days.
Uncomplicated UTI 250 or 500 mg every 12 hr for 7-10 days.
Early Lyme disease 500 mg every 12 hr for 20 days.
Powd for inj Adult 750 mg-1.5 g every 6-8 hr for 2-10 days.
Uncomplicated UTI, skin & skin structure infections, disseminated gonococcal infections, uncomplicated pneumonia 750 mg IV every 8 hr.
Severe infection 1.5 IV every 8 hr.
Bone & joint infections 1.5 g IV every 8 hr.
Bacterial meningitis 3 g IV every 8 hr.
Life-threatening infections or infections due to less susceptible organisms 1.5 g IV every 6 hr.
Uncomplicated gonococcal infections 1.5 g IM as single dose given at 2 different sites + 1 g PO probenecid.
Surgical prophylaxis: Biliary surgery 1.5 g IV single dose,
cardiac surgery 1.5 g pre-op then 1.5 g IV every 12 hr for 48 hr,
vascular surgery 1.5 g pre-op then 1.5 g IV every 8 hr for 24 hr,
orthopedic surgery 1.5 pre-op then 750 mg IV every 8 hr for 24 hr.
Childn 50-150 mg/kg/day IV in 3-4 divided doses 2-10 days.
Mild to moderate infections Childn 10-12 yr 750 mg every 6-8 hr. Total daily dose: 2,250 mg,
6-10 yr 500 mg every 6-8 hr. Total daily dose: 1,500 mg,
2-8 yr 250 mg every 6-8 hr. Total daily dose: 1,000 mg,
10-24 mth 250 mg every 6-8 hr. Total daily dose: 750 mg,
6-9 mth 125 mg. Total daily dose: 500 mg,
3-6 mth 125 mg 6-8 hr. Total daily dose: 375 mg.
Severe infections Childn 10-12 yr 1,500 mg every 6-8 hr. Total daily dose: 4,500 mg,
6-10 yr 750 mg every 6-8 hr. Total daily dose 3,000 mg,
2-8 yr 500 mg every 6-8 hr. Total daily dose: 2,250 mg,
10-24 mth 500 mg every 6-8 hr. Total daily dose: 1,500 mg,
6-9 mth 375 mg every 6-8 hr. Total daily dose: 1,125 mg,
3-6 mth 250 mg every 6-8 hr. Total daily dose: 750 mg.
Renal impairment CrCl >20 mL/min 750 mg-1.5 g every 8 hr,
10-20 mL/min 750 mg every 12 hr,
<10 mL/min 750 mg every 24 hr.