Zegen Adverse Reactions

Tablet: The following adverse events have been reported with the use of cefuroxime, although in many instances the causal relationship to the drug has not been established: Dermatologic/Hypersensitivity Reaction: Rash (e.g., morbilliform), hives, erythema, pruritus, urticaria, drug fever, anaphylaxis (very rarely), angioedema, serum sickness-like reaction, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis (exanthemic necrolysis), shortness of breath and severe bronchospasm.
Gastrointestinal (GI): Diarrhea or loose stools, nausea, vomiting, abdominal pain/cramps, gagging, epigastric burning, epigastric pain/dyspepsia, flatulence, indigestion, GI bleeding, mouth ulcers, swollen tongue, dislike of taste, stomach cramps, anorexia, thirst, GI infection, ptyalism, pseudomembranous colitis.
Genitourinary: Urethral pain or bleeding, kidney pain, urinary tract infection, dysuria, acute renal failure/dysfunction, interstitial nephritis, transient increases in blood urea nitrogen (BUN) and serum creatinine concentrations; decreased creatinine clearance; bilateral renal cortical necrosis, vaginitis, vaginal candidiasis, vulvovaginal pruritus, vaginal discharge or irritation, menstrual irregularities.
Hematologic: Eosinophilia, neutropenia, hemolytic anemia, leukopenia, pancytopenia, thrombocytopenia, thrombocytosis, lymphocytosis; increased prothrombin time; increased erythrocyte sedimentation rate, decreased hemoglobin and/or hematocrit, positive Coombs' test.
Hepatic: Transient elevations in aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ-glutamyl transferase, alkaline phosphatase, lactate dehydrogenase (LDH), and bilirubin; jaundice, hepatic impairment including hepatitis and cholestasis, decreased serum albumin and/or total protein.
Musculoskeletal: Muscle spasm of the neck, muscle cramps or stiffness, arthralgia/joint pain or swelling.
Nervous System: Headache, dizziness, somnolence/sleepiness, irritable behavior, seizures, myoclonic jerks, generalized hyperexcitability/hyperactivity.
Respiratory: Pleural effusion, pulmonary infiltrate, dyspnea or respiratory distress, upper respiratory infection, rhinitis, sinusitis, cough.
Cardiovascular: Chest pain or tightness, tachycardia.
Other Adverse Effects: Jarisch-Herxheimer reaction in patients treated for Lyme disease, candidiasis/candida overgrowth, mild to severe hearing loss, increased or decreased serum glucose concentration, lockjaw-type reaction, viral illness.
Powder for Injection: Dermatologic and Hypersensitivity Reactions: Rash (e.g., morbilliform), fever, pruritus, erythema, urticaria, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, serum sickness-like reactions, angioedema, and anaphylaxis.
Gastrointestinal Effects: Nausea, vomiting, diarrhea or loose stools, strong, persistent, bitter taste; gagging, burning epigastric pain, gastrointestinal bleeding; flatulence; gastrointestinal infection; ptyalism; indigestion; mouth ulcers; swollen tongue; anorexia; thirst; dyspepsia, and stomach cramps.
Hematologic Effects: Decreased hematocrit and hemoglobin concentration; transient eosinophilia and neutropenia; pancytopenia; thrombocytopenia; leucopenia; thrombocytosis; lymphocytosis; hemolytic anemia, and increased prothrombin time.
Central Nervous System Effects: Headache, dizziness, somnolence or sleepiness; hyperactivity, irritable behavior, seizures, myoclonic jerks, and generalized hyperexcitability.
Hepatic Effects: Jaundice; transient increases in serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase, lactate dehydrogenase (LDH), and bilirubin concentrations.
Renal and Genitourinary Effects: Acute renal failure and interstitial nephritis have been reported rarely in patients receiving cefuroxime.
Bilateral renal cortical necrosis that appeared to be a hypersensitivity reaction has occurred in one patient receiving oral cefuroxime. Urinary tract infection, kidney pain, urethral pain or bleeding, dysuria; vaginitis, vaginal candidiasis; vulvovaginal pruritus, and vaginal discharge or irritation have also been reported with oral cefuroxime.
Other Effects: Jarisch-Herxheimer reaction has occurred in patients receiving oral cefuroxime for the treatment of Lyme disease. Mild to severe hearing loss has been reported in a few pediatric patients receiving cefuroxime. Muscle spasm of the neck, muscle cramps or stiffness, chest pain or tightness, shortness of breath, upper respiratory infection, sinusitis, fever, cough, lockjaw-type reaction, viral illness, tachycardia, chills, sinusitis, fever, cough, joint swelling, and arthralgia have been reported in less than 1% of patients receiving oral cefuroxime. Diaper rash has been reported in 3.4% of pediatric patients receiving oral cefuroxime.