Clozapine may enhance central effects of alcohol, MAO inhibitors, CNS depressants including narcotics, benzodiazepines and sedative antihistaminics. Caution is advised with patients who are receiving (or have recently received) benzodiazepines as the increased risk of circulatory collapse accompanied by respiratory depression are involved. Because of the additive effects, caution should be applied with concomitant administration of drugs with anticholinergic, hypotensive or respiratory depression effects. Other drugs which may have the potential to depress bone-marrow function (e.g. Carbamazepine, Captopril, and Propythiouracil), may increase the risk of agranulocytosis associated with clozapine.
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