Pharmacology: Clozapine is classified as an atypical antipsychotic agent, which differs from conventional antipsychotics. It has a weak dopamine receptor blocking activity at D2 receptors, but has a D1 anti-adrenergic, anticholinergic, antihistaminergic and arousal reaction inhibiting effects. It has also been shown to possess antiserotonergic property. Clozapine produces rapid and marked sedation and exerts strong antipsychotic effects. It is effective in patients exhibiting both positive and negative schizophrenic symptoms.
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