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Symptoms of overdosage are drowsiness, lethargy, coma, areflexia, confusion, agitation, hyperflexia, delirium, convulsions, hypersalivation, mydriasis, blurred vision, thermolability, tachycardia, hypotension, collapse, cardiac arrhythmia and respiratory depression. Management of overdosage include gastric lavage followed by administration of activated charcoal, symptomatic treatment under continuous cardiac monitoring, surveillance of respiration, control of electrolytes and acid base balance. The use of adrenaline and its derivative should be avoided for treatment of hypotension because of possibility of "reverse adrenaline" effect.
Close medical supervision is necessary for at least four days because of possibility of delayed reactions.
