Management of manifestations of acute & chronic psychosis including schizophrenia & manic states; severe behavior problems in childn who have combative, explosive hyperexcitability & in the symptomatic control of Gilles de la Tourette's syndrome.
AdultPsychoses & associated behavior disorders Initially 0.5-5 mcg bid-tid. Severe psychoses or resistant patient Doses of up to 100 mcg daily may be required. Reduce dose gradually according to response. Maintenance: 3-10 mcg daily. Childn Initially 25-50 mcg/kg daily in 2 divided doses, increase cautiously if necessary.
Risk of tardive dyskinesia, neuroleptic malignant syndrome. Contributory to precipitation of anginal attacks (very rare instances). Moderate hypotension w/ excessive dose. Vertigo & syncope rarely occur. May lower convulsive threshold & trigger seizures in previously controlled known epileptics. Patients w/ severe liver or kidney impairment; or those w/ allergy to other neuroleptic drugs. Avoid abrupt w/drawal on patients on maintenance treatment. May impair ability to drive or operate machinery. Pregnancy & lactation.
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