Pharmacology: Pharmacokinetics: Haloperidol is readily absorbed from the gastrointestinal tract. It is metabolized in the liver and excreted in the urine and, via the bile, in the feces there is evidence of enterohepatic recycling. Owing to the first-pass effect of metabolism in the liver, plasma concentrations following oral administration are lower than those following intramuscular administration. Haloperidol is about 92% bound plasma proteins. It is widely distributed in the body and crosses the blood-brain barrier. The decanoate ester of Haloperidol is very slowly absorbed from the site of injection, it is gradually released into the bloodstream where it is rapidly hydrolysed to haloperidol.