Pharmacology: Pharmacokinetics: Absorption is independent of food intake (mean Tmax is 4 hours after multiple dosing). The apparent volume of distribution (Vd, beta/F) after oral administration is about 12 to 26 L/kg. The plasma protein binding of Escitalopram is approximately 55%. Escitalopram is metabolised in the liver to the didemethylated metabolites are partly excreted as glucoronides. Unchanged Escitalopram is the predominant compound in plasma. After multiple dosing the mean concentrations of the dimethyl and didemethyl metabolites are usually 28-31 % and 5% of the Escitalopram concentration, respectively. The elimination half-life after multiple dosing is about 30 hours and the oral plasma clearance is about 0.60L/min. Escitalopram and major metabolites are like racemic citalopram assumed to be eliminated by the hepatic (metabolic) and renal routes with the major part of the dose.
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