Abilify Overdosage

MedDRA terminology has been used to classify the adverse reactions.
Human Experience: In clinical trials and in post marketing experience, adverse reactions of deliberate or accidental over dosage with ABILIFY have been reported worldwide. These include overdoses with ABILIFY alone and in combination with other substances. No fatality was reported with ABILIFY alone. The largest known dose with a known outcome involved acute ingestion of 1,260 mg of ABILIFY (42 times the maximum recommended daily dose) by a patient who fully recovered. Deliberate or accidental over dosage was also reported in children (age 12 years and younger) involving ABILIFY ingestions up to 195 mg with no fatalities.
Common adverse reactions (reported in at least 5% of all overdose cases) reported with ABILIFY over dosage (alone or in combination with other substances) include vomiting, somnolence, and tremor. Other clinically important signs and symptoms observed in one or more patients with ABILIFY overdoses (alone or with other substances) include acidosis, aggression, aspartate aminotransferase increased, atrial fibrillation, bradycardia, coma, confusional state, convulsion, blood creatine phosphokinase increased, depressed level of consciousness, hypertension, hypokalaemia, hypotension, lethargy, loss of consciousness, QRS complex prolonged, QT prolonged, pneumonia aspiration, respiratory arrest, status epilepticus and tachycardia.
Management of Over Dosage: No specific information is available on the treatment of overdose with ABILIFY. An electrocardiogram should be obtained in case of over dosage and, if QTc interval prolongation is present, cardiac monitoring should be instituted. Otherwise, management of overdose should concentrate on supportive therapy, maintaining an adequate airway, oxygenation and ventilation, and management of symptoms. Close medical supervision and monitoring should continue until the patient recovers.
Charcoal: In the event of an overdose of ABILIFY, an early charcoal administration may be useful in partially preventing the absorption of aripiprazole. Administration of 50 g of activated charcoal, one hour after a single 15-mg oral dose of ABILIFY, decreased the mean AUC and Cmax of aripiprazole by 50%.
Haemodialysis: Although there is no information on the effect of haemodialysis in treating an overdose with ABILIFY, haemodialysis is unlikely to be useful in overdose management since aripiprazole is highly bound to plasma proteins.