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Administration of fexofenadine within 15 minutes of an aluminum- and magnesium-containing antacids decreased fexofenadine AUC by 41% and Cmax by 43%. Fexofenadine should not be taken closely in time to these antacids. It is advisable to leave 2 hours between administration of fexofenadine hydrochloride and aluminium and magnesium hydroxide containing antacids (for 60 mg).
Coadministration of fexofenadine with erythromycin or ketoconazole may increase fexofenadine plasma levels.
