Bionam

Imipenem 500 mg, cilastatin 500 mg

Infections due to susceptible organisms: Intra-abdominal, skin & soft tissue, GUT, gynecological, lower resp tract, & bone & joint infections; infective endocarditis & septicaemia.

IV Adult Max daily dosage: Should not exceed 50 mg/kg. Weighing ≥70 kg Mild infection 250 mg 6 hrly. Total daily dose: 1 g. Moderate infection 500 mg 8 hrly or 1,000 mg 8-12 hrly. Total daily dose: 1.5 g or 2-3 g, respectively. Severe infection (fully susceptible) 500 mg 6 hrly. Total daily dose: 2 g. Severe &/or life-threatening due to less susceptible organisms (primarily some strains of P. aeruginosa) 500 mg 6-8 hrly or 500-1,000 mg 6 hrly. Total daily dose: 3 g or 4 g, respectively. Renal impairment: Total daily dose of 1 g/day: CrCl ≥71 mL/min/1.73 m² w/ body wt of ≥70 kg 250 mg 6 hrly, 60 kg 250 mg 8 hrly, 50 kg 125 mg 6 hrly; CrCl 41-70 mL/min/1.73 m² w/ body wt of ≥70 kg 250 mg 8 hrly, 60 kg 125 mg 6 hrly, 50 kg 125 mg 6 hrly; CrCl 21-40 mL/min/1.73 m² w/ body wt of ≥70 kg 250 mg 12 hrly, 60 kg 250 mg 12 hrly, 50 kg 125 mg 8 hrly; CrCl 6-20 mL/min/1.73 m² w/ body wt of ≥70 kg 250 mg 12 hrly, 60 kg 125 mg 12 hrly, 50 kg 125 mg 12 hrly. Total daily dose of 1.5 g/day: CrCl ≥71 mL/min/1.73 m² w/ body wt of ≥70 kg 500 mg 8 hrly, 60 kg 250 mg 6 hrly, 50 kg 250 mg 6 hrly; CrCl 41-70 mL/min/1.73 m² w/ body wt of ≥70 kg 250 mg 6 hrly, 60 kg 250 mg 8 hrly, 50 kg 250 mg 8 hrly; CrCl 21-40 mL/min/1.73 m² w/ body wt of ≥70 kg 250 mg 8 hrly, 60 kg 250 mg 8 hrly, 50 kg 250 mg 12 hrly; CrCl 6-20 mL/min/1.73 m² w/ body wt of ≥70 kg 250 mg 12 hrly, 60 kg 250 mg 12 hrly, 50 kg 250 mg 12 hrly. Total daily dose of 2 g/day: CrCl ≥71 mL/min/1.73 m² w/ body wt of ≥70 kg 500 mg 6 hrly, 60 kg 500 mg 8 hrly, 50 kg 250 mg 6 hrly; CrCl 41-70 mL/min/1.73 m² w/ body wt of ≥70 kg 500 mg 8 hrly, 60 kg 250 mg 6 hrly, 50 kg 250 mg 6 hrly; CrCl 21-40 mL/min/1.73 m² w/ body wt of ≥70 kg 250 mg 6 hrly, 60 kg 250 mg 8 hrly, 50 kg 250 mg 8 hrly; CrCl 6-20 mL/min/1.73 m² w/ body wt of ≥70 kg 250 mg 12 hrly, 60 kg 250 mg 12 hrly, 50 kg 250 mg 12 hrly. Total daily dose of 3 g/day: CrCl ≥71 mL/min/1.73 m² w/ body wt of ≥70 kg 1,000 mg 8 hrly, 60 kg 750 mg 8 hrly, 50 kg 500 mg 6 hrly; CrCl 41-70 mL/min/1.73 m² w/ body wt of ≥70 kg 500 mg 6 hrly, 60 kg 500 mg 8 hrly, 50 kg 500 mg 8 hrly; CrCl 21-40 mL/min/1.73 m² w/ body wt of ≥70 kg 500 mg 8 hrly, 60 kg 500 mg 8 hrly, 50 kg 250 mg 6 hrly; CrCl 6-20 mL/min/1.73 m² w/ body wt of ≥70 kg 500 mg 12 hrly, 60 kg 500 mg 12 hrly, 50 kg 250 mg 12 hrly. Total daily dose of 4 g/day: CrCl ≥71 mL/min/1.73 m² w/ body wt of ≥70 kg 1,000 mg 6 hrly, 60 kg 1,000 mg 8 hrly, 50 kg 750 mg 8 hrly; CrCl 41-70 mL/min/1.73 m² w/ body wt of ≥70 kg 750 mg 8 hrly, 60 kg 750 mg 8 hrly, 50 kg 500 mg 6 hrly; CrCl 21-40 mL/min/1.73 m² w/ body wt of ≥70 kg 500 mg 6 hrly, 60 kg 500 mg 8 hrly, 50 kg 500 mg 8 hrly; CrCl 6-20 mL/min/1.73 m² w/ body wt of ≥70 kg 500 mg 12 hrly, 60 kg 500 mg 12 hrly, 50 kg 500 mg 12 hrly. Childn ≥3 mth Non-CNS infections 15 mg/kg 6 hrly. Total daily dose: Not to exceed 2 g, >40 kg Adult dosage should be used.

Hypersensitivity. Meningitis.

Hypersensitivity to penicillins, cephalosporins or other β-lactam antibiotics. Discontinue if allergic reaction occurs. Patients w/ CrCl <5 mL/min/1.73 m². Superinfection may occur in prolonged use. Discontinue use in patients who present w/ diarrhea subsequent to therapy; Pseudomembranous colitis. Do not administer IV to childn w/ meningitis. Pregnancy & lactation. 

Pains, thrombophlebitis at the site of inj; urticaria, rash, pruritus, erythema multiforme, TEN & SJS; nausea, vomiting, diarrhea, pseudomembranous colitis, hepatitis, jaundice; increased eosinophils, agranulocytosis, thrombocytopenia, thrombocytosis, +ve direct Coombs' test; increased transaminases, alkaline phosphatase & bilirubin; seizures; decreased blood Na level, increased blood K & Cl level.

Generalized seizures w/ ganciclovir.

Other Beta-Lactams

J01DH51 - imipenem and cilastatin ; Belongs to the class of carbapenems. Used in the systemic treatment of infections.

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