Duration of treatment should be based on the type or severity of infection. Treatment should be continuous until recovery and/or treat for at least 2 days further after the symptom of infection disappear. However, the effectiveness/safety of treatment more than 14 days have not been established.
Adults: Treatment: Dosage schedule for patients with normal renal function should be based on severity of infections. The maximum daily dosage should not exceed 50 mg/kg. (See Table 1.)
![](https://mpfshstrg.blob.core.windows.net/mpf-uat-common-resources/Images/monograph/table.gif)
Treatment: Dosage schedule for patients with impaired renal function should be reduced appropriate. Using the table as follows, find the appropriate reduced dosing schedule. (See Table 2.)
![](https://mpfshstrg.blob.core.windows.net/mpf-uat-common-resources/Images/monograph/table.gif)
Use in children: BIONAM is not recommended for Intravenous injection in the therapy of meningitis because it may cause seizures. Clinical data are insufficient to recommend dosing for children under 30 kg weight, or pediatric patients with impaired renal function.
3 months or older (Non-CNS infections): 15 mg/kg every 6 hours. The total daily dose should not exceed 2 g. In children over 40 kg weight, adult dosage should be used.