Bionam Special Precautions

Do not reconstitute BIONAM with solution that have benzyl alcohol before given in children because it may cause toxicity from benzyl alcohol.
BIONAM can cause rapid resistant especially in some strain of Pseudomonas aeruginosa.
Prolonged use may occasionally result in overgrowth of nonsusceptible organisms. Pseudomembranous colitis has been reported and may range in severity from mild to life-threatening. It is important, therefore, to consider this diagnosis in patients who present with diarrhea subsequent to the administration of BIONAM, should be discontinued. If have severe Pseudomembranous colitis, the appropriate antibiotic should be used for treatment Clostridium difficile that cause colitis.
Before therapy with BIONAM is instituted, careful inquiry should be made concerning previous hypersensitivity reaction to either penicillins, cephalosporins or other beta-lactam antibiotics. If an allergic reaction occurs, the drug should be discontinued.
Patients with creatinine clearance of <5 mL/min/1.73m² should not receive BIONAM.
Children with meningitis should not receive BIONAM by intravenous injection because it may cause seizures.