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Pharmacology: Pharmacodynamics/Pharmacokinetics: Onset of action: Analgesic: 30-60 minutes; Anti-inflammatory: ≤ 7 days.
Duration: Oral: 4-6 hours.
Absorption: Oral: Rapid (85%).
Distribution: Vd: 6.35 L; Premature infants (highly variable between studies): Day 3: 160-328 mL/kg; Subset with ductal closure: 145-349 mL/kg.
Day 5: 94-248 mL/kg; Subset with ductal closure: 72-222 mL/kg.
Protein binding: 90% to 99%; Premature infants: ~95%.
Metabolism: Hepatic via oxidation.
Half-life elimination: Premature infants (highly variable between studies): 23-75 hours.
Children 3 months to 10 years: 1.6 ± 0.7 hours; Adults: 2-4 hours; End-stage renal disease: Unchanged.
Time to peak: Oral: ~1-2 hours.
Excretion: Urine (primarily as metabolites; 1% as unchanged drug); some feces.
