Brusoft Warnings

It is contraindicated in patients who have previously exhibited hypersensitivity to the drug or in individuals with the syndrome of asthma, rhinitis, angioedema or urticaria in response to aspirin, or other non-steroidal anti-inflammatory drugs (NSAIDs).
It is especially important not to use the drug during third trimester of pregnancy unless specifically directed to do so by a physician.
It is contraindicated in patients with active or history of recurrent gastrointestinal bleeding or peptic ulceration.
It is contraindicated in patients with severe hepatic failure and renal failure.
It is contraindicated in patients with dengue hemorrhagic fever.
If the drug with a rash or symptoms similar to flu, stop the medicine and consult a doctor immediately.
NSAIDs may cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines.
NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke. This risk may increase with high dosage and duration of use.
Fluid retention and peripheral edema have been observed in some patients receiving the drug; therefore, the drug should be used with caution in patients with a history of cardiac decompensation or renal function impairment.
Caution is advised when the drug is required in hypertension and elderly.
The drug may decrease platelet aggregation and prolong bleeding time. Because this prolonged bleeding effect may be exaggerated in patients with underlying hemostatic defects, it should not be used in suspected patient with dengue hemorrhagic fever or persons with intrinsic coagulation disorders and those on anticoagulant therapy.
When using this medication, if the symptoms are as follows such as fever, rash, Epidermolysis bullosa, the stripping of the skin and the mucous membrane, such as in the oral cavity, throat, nose, sexual organs and Conjunctivitis, stop and consult a physician because it may be Stevens-Johnson syndrome.