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Known hypersensitivity to chlorthalidone, other sulfonamide-derivative drugs, or any component of the formulation, renal decompensation, hepatic coma or precoma, anuria.
Although allergy to other sulfonamide derivatives is a contraindication, evidence to support cross-sensitivity is limited, and a history of sensitivity to sulfonamide anti-infectives ("sulfa sensitivity") should not be considered an absolute contraindication to non-anti-infective sulfonamide such as Thiazides.
The routine use of thiazide is contraindicated in pregnant women with mild edema who are otherwise healthy.
Gout: Thiazides can increase serum uric acid concentrations. Although the drugs rarely induce acute gout, they generally should be avoid or used with caution in patients with a history of gout or elevated uric acid concentrations.
