Chotalin Use In Pregnancy & Lactation

Use in Pregnancy: Pregnancy Category B.
Thiazide diuretics cross the placenta and are found in cord blood. Maternal use may cause fetal or neonatal jaundice, thrombocytopenia or other adverse events observed in adults.
The routine use of thiazide is contraindicated in pregnant women with mild edema who are otherwise healthy.
Use in treating edema during normal pregnancies is not appropriate; use may be considered when edema is due to pathologic causes (as in non-pregnant women).
May use only when the potential benefits outweigh the possible risk to the fetus or neonate.
Thiazide diuretics may be used as second-line antihypertensive agents and may be particular useful in sodium sensitive women. If initiation of antihypertensive therapy is necessary during pregnancy (chronic hypertension with persistent severely elevated blood pressure), other antihypertensives (i.e., methyldopa, nifedipine, labetalol) are recommended.
In women who are already receiving antihypertensive therapy prior to pregnancy, treatment decisions, whether to continue or discontinue, should be individualized.
Thiazide diuretics are not recommended for prevention or management of gestational hypertension or preeclampsia.
Use in Lactation: Thiazides are excreted into breast milk. Due to the potential for serious adverse reactions in the breast-feeding infant, recommend a decision be made whether to discontinue nursing or the drug, taking into account the importance of treatment to the mother. Diuretics have the potential to decrease milk volume and suppress lactation.