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Clexane is a low-molecular weight heparin (MW approximately 4500 D) obtained by controlled depolymerisation of a benzyl ester of natural porcine heparin. In comparison with natural heparin, it is characterised by a clear increase in the ratio between anti-Xa and anti-IIa activities which is always >4.
As a result, antithrombotic activity is increased relative to the anticoagulant activity. It has a high affinity for antithrombin III and a dual action on the coagulation mechanism inhibiting prothrombinase activity (factor Xa, co-factor V, calcium and phospholipid) and inactivating thrombin. The antithrombotic activity is related to other factors in addition to anti-Xa activity.
