Histan Overdosage

Overdose and treatment: Anticholinergic (primarily antimuscarinic) effects develop in overdose. Mild to moderate poisoning effects for example somnolence, anticholinergic effects (i.e., mydriasis, flushing, fever, dry mouth, and decreased bowel sounds), tachycardia, mild hypertension, and nausea and vomiting are common after overdose. Agitation, confusion, and hallucinations may develop with moderate poisoning. Severe poisoning effects may include agitated delirium, psychosis, seizures, coma, hypotension, QRS widening, and ventricular dysrhythmias, including torsade de pointes but are generally only reported in adults after very large, deliberate ingestions.
In the event of an overdose, supportive management is recommended. However, hemodialysis or peritoneal dialysis is probably not effective in enhancing elimination of Hydroxyzine. There is no specific antidote for Hydroxyzine intoxication. Activated charcoal should be given if patient presents shortly after ingestion; sedate with benzodiazepines for agitation and delirium. If hypotension occurs, it may be controlled with IV fluids and norepinephrine or metaraminol; epinephrine should not be used. Further management, such as patients with severe toxicity (i.e., seizures, dysrhythmias, severe delirium, coma) or in whom the diagnosis is not clear, should be as clinically indicated or as recommended by the poison center, where available. A patient with a deliberate overdose requires a psychiatric evaluation prior to discharge.