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QT prolongation/torsades de pointes has been reported with the majority occurring in patients with other risk factors for QT prolongation/torsades de pointes (e.g., preexisting cardiac disease, electrolyte imbalances, concomitant arrhythmogenic use). Use with caution in patients with risk factors for QT prolongation, congenital long QT syndrome, a family history of long QT syndrome, other conditions that predispose to QT prolongation and ventricular arrhythmia, as well as recent myocardial infarction, uncompensated heart failure, and bradyarrhythmias.
Use with caution with narrow-angle glaucoma, prostatic hyperplasia, urinary stricture, asthma, or COPD.
Effect on ability to drive and use machine: Hydroxyzine may cause CNS depression, which may impair physical or mental abilities; patients must be cautioned about performing tasks that require mental alertness (e.g., operating machinery or driving).
