Ketocetz

Ketocetz

ketorolac

Manufacturer:

Gland Pharma

Distributor:

Zuellig Pharma

Marketer:

Mega Lifesciences
Concise Prescribing Info
Contents
Ketorolac tromethamine
Indications/Uses
Short-term management (≤5 days) of moderately severe acute pain, usually in post-op setting.
Dosage/Direction for Use
IM/IV Administer IM slowly & deeply into the muscle or as IV bolus over no <15 sec. Adult w/ normal renal function 60 mg IM or 30 mg IV as single-dose treatment, or 30 mg IV/IM every 6 hr as multiple-dose treatment. Max: 120 mg daily. Elderly, patients weighing <50 kg, renal impairment Reduce dose to 30 mg IM or 15 mg IV as single-dose treatment, or 15 mg IV/IM every 6 hr as multiple-dose treatment. Max: 60 mg daily.
Contraindications
Hypersensitivity to ketorolac, aspirin, or other NSAIDs. Patients w/ increased risk of bleeding eg, CABG surgery, cerebrovascular bleeding, PUD & GI bleeding, hemostasis disorders. Neuraxial (epidural or intrathecal) administration. Concomitant use w/ drug affecting hemostasis & before major surgery. Renal impairment. Pregnancy & lactation.
Special Precautions
Not to be used in elevated CV risk patients, particularly for perioperative pain in CABG surgery. Total combined duration of oral & inj use should not exceed 5 days. Closely monitor signs & symptoms of GI risk. Active & history of PUD, recent GI bleeding or perforation, history of bleeding. Increased risk of serious thrombotic events, MI or stroke; bleeding. Patients w/ pre-existing CV diseases. Avoid in patients w/ bleeding disorders, current or history of serious hemorrhagic events & those at high risk of bleeding. Contraindicated as prophylactic analgesic before any major surgery; for intrathecal or epidural administration. Severe renal impairment. Contraindicated in labor & delivery. Not to be used in lactating women.
Adverse Reactions
Edema, HTN; inj site pain, pruritus, rash, sweating; abdominal pain, constipation, diarrhea, flatulence, heartburn, indigestion, nausea, stomatitis, vomiting; anemia, purpura; dizziness, headache, somnolence; burning sensation in eye, corneal edema, eye infection, irritation & pain, iritis, superficial keratitis; nasal irritation, nose pain. MI, thrombotic tendency observations; erythroderma, SJS, TEN; GI hemorrhage, perforation & ulcer, melena; blood coagulation disorder w/ prolonged bleeding time, hematoma, hemorrhage, post-op hemorrhage; hepatitis, hepatotoxicity, increased LFT, jaundice; anaphylactoid reaction; CVA; corneal thinning & perforation; hearing loss; kidney injury, interstitial nephritis, nephrotic syndrome, renal failure; bronchospasm, dyspnea, pulmonary edema.
Drug Interactions
Increased conc & toxicity w/ probenecid. Increased risk of serious NSAID-related adverse reactions w/ other NSAIDs, or aspirin. Increased bleeding tendency w/ pentoxifylline. Not to be used concomitantly w/ ACE inhibitors & ARBs, antidepressants (eg, TCAs, SNRIs & SSRIs), antiplatelets & anticoagulants, β-adrenergic blockers, cyclosporine, digoxin, diuretics (eg, K-sparing, thiazide & loop diuretics), fluoroquinolones, lithium, MTX & derivatives (eg, pemetrexed & pralatrexate), oral corticosteroids, tenofovir disoproxil fumarate. Precipitation w/ morphine, meperidine, promethazine or hydroxyzine.
MIMS Class
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
ATC Classification
M01AB15 - ketorolac ; Belongs to the class of acetic acid derivatives and related substances of non-steroidal antiinflammatory and antirheumatic products.
Presentation/Packing
Form
Ketocetz soln for inj 30 mg/mL
Packing/Price
2 mL x 10 × 1's
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