Hypersensitivity reaction to ketorolac, aspirin, other NSAIDs, or any product component.
Patients with increased risk of bleeding includes CABG surgery, cerebrovascular bleeding, peptic ulcer disease and gastrointestinal bleeding, hemostasis disorders, concomitant use with drug affecting hemostasis, and before major surgery.
Patients with renal impairment.
Pregnancy and lactation women.
Neuraxial (epidural or intrathecal) administration.