Ketorolac, a pyrrolozine carboxylic acid derivative, is a member of the non-steroidal anti-inflammatory agents (NSAIDs). The drug possesses anti-inflammatory, analgesic, and antipyretic activity by inhibition of prostaglandin synthesis. Both cyclooxygenase (COX) isozymes (COX-1 and COX-2) are target of the drug action. The tromethamine moiety enhances the aqueous solubility of ketorolac. Ketorolac tromethamine is an off-white crystalline powder that has solubilities of 3 mg/mL and more than 500 mg/mL in alcohol and water at 23°C, respectively.
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