W/draw treatment if there is symptoms of ruptures of shoulder, hand & achilles tendons that required surgical repair/prolonged disability. Discontinue use at 1st appearance of skin rash or any sign of hypersensitivity. Increased ICP & central confusion, hallucinations, paranoia, depression, nightmares, insomnia, suicidal thoughts/acts. Patient w/ CNS disorders predispose to seizures; existing heart problems; arrhythmia; HTN or low blood K. Convulsions & toxic psychoses. Antibiotic-associated colitis. May cause phototoxicity reaction eg, TEN, SJS, erythema multiforme. May alter blood glucose level. Consider fluid & electrolytes management, protein supplementation & drug treatment clinically effective against
C. difficile colitis. Avoid in concomitant use w/ drugs prolonging QT interval eg, quinidine, procainamide, amiodarone, cisapride, erythromycin, antipsychotics, TCAs. Increased pharmacological action of warfarin. Renal impairment CrCl <50 mL/min. Not to be used during pregnancy & lactation. Adolescents <18 yr & childn.
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