Monem Special Precautions

As with other beta-lactam antibiotics rare hypersensitivity reactions have been reported.
Before therapy with MONEM is instituted, careful inquiry should be made concerning previous hypersensitivity reaction to beta-lactam antibiotics. If an allergic reaction occurs, the drug should be discontinued.
Use of MONEM in patients with hepatic disease should be made with careful monitoring of transaminase and bilirubin levels.
Use in infections caused by methicillin resistant staphylococci is not recommended.
Prolonged use may occasionally result in overgrowth of nonsusceptible organisms.
Pseudomembranous colitis has been reported with nearly all antibiotics, including MONEM, and may range in severity from mild to life-threatening. It is important, therefore, to consider this diagnosis in patients who present with diarrhea subsequent to the administration of any antibiotics. After diagnosis of pseudomembranous colitis has been established, therapeutic measures should be initiated.
Although studies indicate that a toxin produced by Clostridium difficile is one of the main caused of antibiotic-associated colitis, other causes should be considered.
The co-administration of MONEM with potentially nephrotoxic drugs should be considered with caution. (For dosage see Dosage & Administration.)
Effects on ability to drive and use machines: There is no evidence to suggest that meropenem may have an effect on a patient's ability to drive or operate machinery.