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As a polypeptide, calcitonin very occasionally causes local or generalized hypersensitivity reactions. In patients with a history of such reactions, a skin test before beginning treatment with the drug may be needed.
Nasal examinations should be performed before treatment begins and any time that nasal complaints occur.
Chronic rhinitis may increase the bioavailability of the intranasally administered calcitonin and patients with this condition should be carefully monitored if they are using the nasal spray.
There is report that long-term use of calcitonin raises cancer risk.
Use in Children: Human calcitonin or salmon calcitonin has been used rarely in children with Juvenile Paget's Disease, but the relationship of these pediatric bone disorders to Paget's Disease in adults has not been established. Currently, there are inadequate safety and efficacy data to support the use of calcitonin in children.
