Ondavell Dosage/Direction for Use

For the Prevention of Chemotherapy and radiotherapy induced nausea and vomiting: Adults and pediatric patients 6 months of age and older: The initial IV dose of Ondansetron is 0.15 mg/kg given as a 15-minute infusion beginning 30 minutes before administration of chemotherapy, and repeated twice at 4-hour intervals following the initial dose.
Alternatively, in adults, a single IV Ondansetron dose of 32 mg may be given as a 15-minute infusion beginning 30 minutes before administration of chemotherapy, this dose should not be repeated.
Elderly: Ondansetron is well tolerated by patients over 65 years old and no alteration of dosage, dosing frequency or route of administration are required.
For the Prevention of Post-operative nausea and vomiting: Adults: The recommended dosage of Ondansetron in adults, is a single dose of 4 mg administered intravenously in not less than 30 seconds, preferably over 2 to 5 minutes immediately before induction of anesthesia or postoperatively if the patient experiences nausea and/or vomiting shortly after surgery.
Children: The recommended dosage of Ondansetron in pediatric patients 1 month to 12 years of age, is a single IV dose of 4 mg in patients weighing more than 40 kg or a single IV dose of 0.1 mg/kg in patients weighing 40 kg or less. The rate of administration should not be less than 30 seconds, preferably over 2 to 5 minutes. The dose should be given immediately before or after induction of anesthesia or postoperatively if the patient experiences nausea and/or vomiting shortly after surgery.
Elderly: Ondansetron is well tolerated by patients over 65 years old and no alteration of dosage, dosing frequency or route of administration are required.
Patients with renal impairment: No alteration of daily dosage, frequency of dosing, or route of administration are required.
Patients with liver impairment: A significant reduction in Ondansetron clearance and significant increase in half life in patient with moderate or severe liver impairment. In such patient a total daily dose should not exceed 8 mg.