Sixime Mechanism of Action

Pharmacology: Pharmacodynamics: Cefixime is generally classified as a third-generation cephalosporin antibacterial. Cefixime, a semisynthetic cephalosporin, is a broad-spectrum bactericidal agent that inhibits cell wall synthesis and is stable in the presence of certain beta-lactamases. The antibacterial activity of the drug results from inhibition of mucopeptide synthesis in the bacterial cell wall. Cefixime is given orally to treat infections due to susceptible Gram-positive and Gram-negative bacteria, including gonorrhea and infections of the respiratory and urinary tracts.
Pharmacokinetics: Approximately 30-50% of a single dose of Cefixime is absorbed following oral administration. The time to peak concentration for oral administration is range 2-8 hours. Cefixime is approximately 65-70% bound to serum proteins, principally albumin. Metabolites with antimicrobial activity were not detected in the serum or urine. Cefixime is eliminated by renal and nonrenal mechanism. Approximately 7-41% of a single dose of Cefixime is excreted unchanged in urine within 24 hours. The serum elimination half-life of Cefixime in adults with normal renal function average 2.4-4 hours.