Sixime Special Precautions

Use with caution in patients with a history of penicillin allergy.
Patients with a personal or familial history of some form of allergy such as bronchial asthma, rash, urticarial.
Modify dosage in patients with renal impairment is necessary.
Patients with poor oral nutrition, Patients receiving parenteral nutrition, elderly patients or patients in a debilitated status. Careful observation is essential in these patients as vitamin K deficiency symptoms may develop.
Superinfection with gram-positive bacteria has occurred in patients receiving Cefixime in prolonged use that may result in overgrowth of nonsusceptible microorganism. If superinfection occurs, appropriate therapy should be instituted.
Like most cephalosporins, Cefixime may cause false-positive results in urinary glucose determinations: however, glucose oxidase methods (e.g. Clinistix, Tes-Tape) are unaffected by the drug.
Cefixime may cause false-positive results for ketones in urine if nitroprusside tests are used; this effect has not been reported with tests using nitroferricyanide.