Single cycle treatment: Continuous IV infusion for 28 days followed by a 14-day treatment-free interval.
Patient ≥45 kg Cycle 1: 9 mcg/day on days 1-7; 28 mcg/day on days 8-28. Allow a 14-day treatment-free interval between cycles. Subsequent cycles: 28 mcg/day on days 1-28, followed by a 14-day treatment-free interval on days 29-42.
<45 kg (BSA-based dose) Cycle 1: 5 mcg/m
2/day (not to exceed 9 mcg/day) on days 1-7; 15 mcg/m
2/day (not to exceed 28 mcg/day) on days 8-28. Allow a 14-day treatment-free interval between cycles. Subsequent cycles: 15 mcg/m
2/day (not to exceed 28 mcg/day) on days 1-28. Allow 14-day treatment-free interval on days 29-42. A treatment course consists of up to 2 cycles of Blincyto for induction followed by 3 additional cycles for consolidation treatment (up to a total of 5 cycles).
Adult Premed w/ dexamethasone 20 mg 1 hr prior to 1st dose of each cycle, prior to step dose (eg, cycle 1 day 8), & when restarting an infusion after an interruption of ≥4 hr.
Ped patient Premed w/ dexamethasone 5 mg/m
2 to a max dose of 20 mg prior to 1st dose of Blincyto (cycle 1), prior to step dose (eg, cycle 1 day 8), & when restarting an infusion after an interruption of ≥4 hr in the 1st cycle.