Cytokine Release Syndrome (CRS): Advise patients of the risk of CRS and infusion reactions, and to contact their healthcare professional for signs and symptoms associated with CRS or infusion reactions (pyrexia, fatigue, nausea, vomiting, chills, hypotension, rash, and wheezing) (see Precautions and Adverse Reactions).
Neurological Toxicities: Advise patients of the risk of neurological toxicities, and to contact their healthcare professional for signs and symptoms associated with this event (convulsions, speech disorders, and confusion) (see Precautions and Adverse Reactions).
Infections: Advise patients of the risk of infections, and to contact their healthcare professional for signs or symptoms of infection (see Precautions and Adverse Reactions).
Inform patients of the importance of keeping the skin clean around the intravenous catheter to reduce the risk of infection.
Pancreatitis: Advise patients of the risk of pancreatitis and to contact their healthcare provider for signs or symptoms of pancreatitis which include severe and persistent stomach pain, with or without nausea and vomiting (see Precautions and Adverse Reactions).
Driving and Engaging in Hazardous Occupations: Advise patients to refrain from driving and engaging in hazardous occupations or activities such as operating heavy or potentially dangerous machinery while BLINCYTO is being administered. Patients should be advised that they may experience neurological events (see Precautions).
Reduce Risk of Infusion Pump Errors: Inform patients they should not adjust the setting on the infusion pump. Any changes to pump function may result in dosing errors. If there is a problem with the infusion pump or the pump alarms, patients should contact their doctor or nurse immediately.