Adult Bladder cancer Combination therapy: 1,000 mg/m
2 as 30 min infusion. Dose should be given in days 1, 8 & 15 of each 28 day cycle in combination w/ cisplatin. Cisplatin is given at 70 mg/m
2 on day 1 following gemcitabine or day 2 of each 28 day cycle.
Pancreatic cancer 1,000 mg/m
2 by 30 min IV infusion, repeated once wkly for up to 7 wk followed by 1 wk rest period. Subsequent cycles should consist of gemcitabine infusions once wkly for 3 consecutive wk out of every 4 wk.
NSCLC Monotherapy: 1,000 mg/m
2 by 30 min IV infusion, repeated once wkly for 3 wk followed by 1 wk rest period. Combination therapy: 1,250 mg/m
2 by 30 min IV infusion on days 1 & 8 of each 21 day cycle. Cisplatin 75-100 mg/m
2 once every 3 wk.
Ovarian cancer Combination therapy w/ carboplatin: 1,000 mg/m
2 by 30 min IV infusion on days 1 & 8 of each 21 day cycle.
Breast cancer Combination therapy w/ paclitaxel: Paclitaxel 175 mg/m
2 IV infused over 3 hr on day 1 followed by gemcitabine 1,250 mg/m
2 IV infused for 30 min on days 1 & 8 of each 21 day treatment cycle.
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