Myelosuppression, paresthesias, and severe rash were the principal toxicities seen when a single dose as high as 5700 mg/m2 can be administered by intravenous infusion over 30 minutes every 2 weeks. In the event of suspected overdose, the patient should be monitored with appropriate blood counts and provide supportive therapy, as necessary. There is no known antidote for overdose of gemcitabine.
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