Auget Dosage/Direction for Use

For the infections caused by amoxicillin-sensitive organisms the dosage is that approved for amoxicillin as the clavulanic acid component does not contribute to the therapeutic effect.
Adults: Tablet: 375 mg: 1-2 tablet every 8 hrs at the start of a meal.
625 mg: Severe Infections and Respiratory Tract Infection: 1 tablet every 8 hrs at the start of the meal or one 1,000 mg tab every 12 hrs at the start of the meal.
Since 375-, 625- and 1000-mg tablets contain the same amount of clavulanic acid (125-mg as the potassium salt), two 375-mg tablets are not equivalent to one 625-mg tablet and are not equivalent to one 1,000-mg tablet. Therefore, two 375-mg tablets should not be substituted for one 625-mg tablet or two 625-mg tablets for one 1000-mg tablet for the treatment of more severe infections.
Amoxicillin Sensitive Organism: Upper and Lower Respiratory Tract, Urinary Tract Infection (UTI), Skin and Soft Tissue Infection: 375 mg: 1-2 tablets every 8 hrs. 625 mg: 1 tablet every 8 hrs. 1,000 mg: 1 tablet every 12 hrs.
Amoxicillin Resistant Organism: 375 mg: Upper (Otitis Media) and Lower (Bronchitis) Respiratory Tract Infections caused by H. influenzae and H. parainfluenzae: 2 tablets every 8 hrs.
UTI (E. coli, K. pneumoniae), Skin and Soft Tissue infections (S. aureus): 1-2 tablets every 8 hrs.
Upper (Otitis Media) and Lower (Bronchitis) Respiratory Tract Infections caused by H. influenzae and H. parainfluenzae, UTI (E. coli, K. pneumoniae), Skin and Soft Tissue infections (S. aureus): 625 mg: 1 tablet every 8 hrs. 1,000 mg: 1 tablet every 12 hrs.
Renal Impairment: Both amoxicillin and clavulanic acid excreted by the kidneys and the serum half-life (t½) of each increases in patients with renal failure. Therefore, the dose may need to be reduced or interval extended. Dosage adjustment are based on the maximum recommended level of amoxicillin.
Mild Impairment [Creatinine Clearance (CrCl) >30 mL/min]: No dosage change.
Moderate Impairment (CrCl 10-30 mL/min): 375 mg or 625 mg tablet once every 12 hrs.
Severe impairment (CrCl <10 mL/min): Not more than one 375 mg tablet every 12 hrs. 625 mg tablets are not recommended.
Children: 25-50 mg/kg/day of the 4 parts amoxicillin, 1 part clavulanic acid preparations (which corresponds to a daily dosage of the equivalent of amoxicillin 40 mg/kg and clavulanic acid 5-10 mg/kg) to be taken in divided doses every 8 hrs at the start of meal. Similar reductions in dosage should be made for children.
Hemodialysis decreases serum concentrations of both amoxicillin and clavulanic acid and additional dose should be administered at the end of dialysis.