Auget Drug Interactions

Probenecid decreases the renal tubular secretion of amoxicillin, but does not affect clavulanic acid excretion. Concomitant use with co-amoxiclav combination may result in increased and prolonged blood levels of amoxicillin but not clavulanic acid.
Prolongation of bleeding time and prothrombin time have been reported in some patients receiving co-amoxiclav combination. Co-amoxiclav combination should be used with care in patients on anticoagulation therapy.
In common with other broad-spectrum antibiotics. Amoxicillin + clavulanate potassium combination may reduce the efficacy of oral contraceptives and patients should be warned accordingly.
The concomitant administration of allopurinol and ampicillin substantially increases the incidence of skin rashes in patients receiving both agents as compared to patients receiving ampicillin alone. It is not known whether this potentiation of ampicillin rashes is due to allopurinol or the hyperuricemia present in this patients. There are no data on amoxicillin + clavulanate potassium combination and allopurinol administered concomitantly.
Following administration of ampicillin to pregnant woman a transient decreases in plasma concentration of total conjugate estriol, estriol glucuronide, conjugated estrone and estradiol has been noted. This effect may also occur with amoxicillin and therefore amoxicillin + clavulanate potassium combination.