Duac Dosage/Direction for Use

Adults and Adolescents: Duac gel is for topical use only.
Children: The safety and efficacy of Duac gel have not been established in children <12 years, therefore this drug is not recommended for use in this population.
Elderly: There are no specific recommendations for use in the elderly.
Renal Impairment: No dosage adjustment is necessary. As percutaneous absorption of Duac gel is low following topical application, renal impairment is not expected to result in systemic exposure of clinical significance.
Hepatic Impairment: Dosage adjustment is necessary. As percutaneous absorption of Duac gel is low following topical application, hepatic impairment is not expected to result in systemic exposure of clinical significance.
Administration: Duac should be applied in a thin film over entire affected area once daily after washing gently with a mild cleanser and fully drying. If the gel does not rub into the skin easily, too much is being applied. Hands should be washed after application. Patients may also use a moisturizer as needed. If excessive dryness or peeling occurs, frequency of application should be reduced or the application is temporarily interrupted.
Efficacy has not been established for less than once daily dosing frequencies. Patients should be advised that excessive application will not improve efficacy, but may increase the risk of skin irritation.
Two (2)-5 weeks of treatment may be required before a therapeutic effect is observed (see Pharmacology: Pharmacokinetics under Actions). The safety and efficacy of Duac gel has not been studied beyond 12 weeks in acne vulgaris clinical trials. The prescriber should evaluate the benefit of continuing treatment beyond 12 weeks of uninterrupted use.