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Signs and Symptoms: Excessive application of Duac may result in severe irritation. In this event, discontinue use and wait until the skin has recovered. Topically applied benzoyl peroxide is not generally absorbed in sufficient amounts to produce systemic effects. Excessive application of topically applied clindamycin may result in absorption of sufficient amounts to produce systemic effects. In the event of accidental ingestion of Duac, gastrointestinal adverse reactions similar to those seen with systemically administered clindamycin may be seen.
Treatment: Appropriate symptomatic measures should be taken to provide relief from irritation due to excessive topical application. Accidental ingestion should be managed clinically or as recommended by the National Poisons Management and Control Center, where available.
